Do randomized controlled clinical trials (RCTs) fall short in addressing the needs of evidence based medicine?
This article from MedPage Today addresses this question. From the article:
There are relatively few trials because of the cost and time requirements. They include only select populations with limited ability to examine subgroups. Too often findings are published only when positive. And surrogate endpoints are used in circumstances where measuring the primary clinical endpoint requires years of study.
Complete article:
MedPage Today article
